Late Ca 2+ Sparks and Ripples During the Systolic Ca 2+ Transient in Heart Muscle Cells
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منابع مشابه
Late Ca2+ Sparks and Ripples During the Systolic Ca2+ Transient in Heart Muscle Cells
RATIONALE The development of a refractory period for Ca2+ spark initiation after Ca2+ release in cardiac myocytes should inhibit further Ca2+ release during the action potential plateau. However, Ca2+ release sites that did not initially activate or which have prematurely recovered from refractoriness might release Ca2+ later during the action potential and alter the cell-wide Ca2+ transient. ...
متن کاملCa(2+) release mechanisms, Ca(2+) sparks, and local control of excitation-contraction coupling in normal heart muscle.
It is well established that most of the Ca 21 that activates contraction in mammalian heart is released from the sarcoplasmic reticulum (SR) through ryanodine receptors (RyR) and that the RyR are themselves activated by Ca in the mechanism known as “Ca induced Ca release” (CICR).1 Confocal imaging has made possible the visualization of localized Ca release through RyR, in the form of Ca sparks....
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Uridine 5'-triphosphate (UTP), a potent vasoconstrictor that activates phospholipase C, shifted Ca(2+) signaling from sparks to waves in the smooth muscle cells of rat cerebral arteries. UTP decreased the frequency of Ca(2+) sparks and transient Ca(2+)-activated K(+) (K(Ca)) currents and increased the frequency of Ca(2+) waves. The UTP-induced reduction in Ca(2+) spark frequency did not reflect...
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Ca release from cardiac sarcoplasmic reticulum (SR) via ryanodine receptors (RyRs) is regulated by dyadic cleft [Ca ] and intra-SR free [Ca ] ([Ca ]SR). Robust SR Ca 2 release termination is important for stable excitation–contraction coupling, and partial [Ca ]SR depletion may contribute to release termination. Here, we investigated the regulation of SR Ca release termination of spontaneous lo...
متن کاملAdrenergic stimulation of rat resistance arteries affects Ca(2+) sparks, Ca(2+) waves, and Ca(2+) oscillations.
Confocal laser scanning microscopy and fluo 4 were used to visualize local and whole cell Ca(2+) transients within individual smooth muscle cells (SMC) of intact, pressurized rat mesenteric small arteries during activation of alpha1-adrenoceptors. A method was developed to record the Ca(2+) transients within individual SMC during the changes in arterial diameter. Three distinct types of "Ca(2+)...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2018
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.117.312257